Three-year results of a randomized, double-blind, controlled trial of mycophenolate mofetil versus azathioprine in cardiac transplant recipients
Identifieur interne : 00A379 ( Main/Exploration ); précédent : 00A378; suivant : 00A380Three-year results of a randomized, double-blind, controlled trial of mycophenolate mofetil versus azathioprine in cardiac transplant recipients
Auteurs : Howard J. Eisen [États-Unis] ; Jon Kobashigawa [États-Unis] ; Anne Keogh [Australie] ; Robert Bourge [États-Unis] ; Dale Renlund [États-Unis] ; Robert Mentzer [États-Unis] ; Edwin Alderman [États-Unis] ; Hannah Valantine [États-Unis] ; Georges Dureau [France] ; Donna Mancini [États-Unis] ; Richard Mamelok [États-Unis] ; Robert Gordon [États-Unis] ; Whedy Wang [États-Unis] ; Mandeep Mehra [États-Unis] ; Maria Rosa Constanzo [États-Unis] ; Manfred Hummel [Allemagne] ; Jay Johnson [États-Unis]Source :
- The Journal of heart and lung transplantation [ 1053-2498 ] ; 2005.
Descripteurs français
- Pascal (Inist)
- Appareil circulatoire pathologie, Appareil respiratoire pathologie, Mycophenolate mofetil, Acide mycophénolique, Mofétil, Long terme, Pronostic, Randomisation, Etude double insu, Immunodépresseur, Etude comparative, Azathioprine, Coeur, Homotransplantation, Chirurgie, Antiviral, Antibiotique, Traitement.
- Wicri :
- topic : Chirurgie, Antibiotique.
English descriptors
- KwdEn :
Abstract
Background: This study reports the 36-month results of a randomized, double-blind, active-controlled trial of mycophenolate mofetil (MMF) vs azathioprine (AZA) in heart transplant patients. Methods: Patients were randomized at the time of transplant to receive MMF (1,500 mg twice a day, N = 327) or AZA (1.5 to 3 mg/kg in 4 daily doses, N = 323) in addition to cyclosporine and corticosteroids; 289 patients in each group received study drug. Data were analyzed in all randomized patients (enrolled) and in patients who received study medications (treated). Clinical and graft assessments continued for 36 months. Results: For the co-primary end-point, 53 of 289 (18.3%) AZA-treated patients either died or received another transplant compared with 34 of 289 (11.8%) MMF-treated patients (p < 0.01). Time to retransplantation or patient death was significantly shorter for AZA- than MMF-treated patients (p = 0.029). In patients undergoing intravascular ultrasound, the change in mean maximal intimal thickness was less for the MMF group than for the AZA group (0.06 ± 0.03 mm vs 0.13 ± 0.03 mm, respectively; p = 0.056). No significant differences between treatments were observed in quantitative coronary angiographic measurements of transplant coronary vasculopathy. Congestive heart failure, atrial arrhythmia and leukopenia were more common in the AZA group, whereas diarrhea, esophagitis, Herpes simplex, Herpes zoster and cytomegalovirus (CMV) tissue invasion were more common in MMF-treated patients. Conclusion: MMF reduces mortality and graft loss up to 36 months after transplantation.
Affiliations:
- Allemagne, Australie, France, États-Unis
- Alabama, Auvergne-Rhône-Alpes, Berlin, Californie, Illinois, Louisiane, New Jersey, Pennsylvanie, Rhône-Alpes, Utah, Wisconsin, État de New York
- Berlin, Lyon
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Le document en format XML
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Eisen</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Drexel University College of Medicine</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Kobashigawa, Jon" sort="Kobashigawa, Jon" uniqKey="Kobashigawa J" first="Jon" last="Kobashigawa">Jon Kobashigawa</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>University of California at Los Angeles</s1><s2>Los Angeles, California</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Keogh, Anne" sort="Keogh, Anne" uniqKey="Keogh A" first="Anne" last="Keogh">Anne Keogh</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>St Vincent's Hospital</s1><s2>Sydney, New South Wales</s2><s3>AUS</s3><sZ>3 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first="Robert" last="Mentzer">Robert Mentzer</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>University of Wisconsin</s1><s2>Madison, Wisconsin</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Alderman, Edwin" sort="Alderman, Edwin" uniqKey="Alderman E" first="Edwin" last="Alderman">Edwin Alderman</name><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Stanford University</s1><s2>Palo Alto, California</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Valantine, Hannah" sort="Valantine, Hannah" uniqKey="Valantine H" first="Hannah" last="Valantine">Hannah Valantine</name><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Stanford University</s1><s2>Palo Alto, California</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Dureau, Georges" sort="Dureau, Georges" uniqKey="Dureau G" first="Georges" last="Dureau">Georges Dureau</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Hospices Civils de Lyon Hopital</s1><s2>Lyon</s2><s3>FRA</s3><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Mancini, Donna" sort="Mancini, Donna" uniqKey="Mancini D" first="Donna" last="Mancini">Donna Mancini</name><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Columbia University College of Physicians and Surgeons</s1><s2>New York, New York</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Mamelok, Richard" sort="Mamelok, Richard" uniqKey="Mamelok R" first="Richard" last="Mamelok">Richard Mamelok</name><affiliation wicri:level="2"><inist:fA14 i1="10"><s1>mamelok Consulting</s1><s2>Palo Alto, California</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Gordon, Robert" sort="Gordon, Robert" uniqKey="Gordon R" first="Robert" last="Gordon">Robert Gordon</name><affiliation wicri:level="2"><inist:fA14 i1="11"><s1>Hoffmann-La Roche</s1><s2>Nutley, New Jersey</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Wang, Whedy" sort="Wang, Whedy" uniqKey="Wang W" first="Whedy" last="Wang">Whedy Wang</name><affiliation wicri:level="2"><inist:fA14 i1="11"><s1>Hoffmann-La Roche</s1><s2>Nutley, New Jersey</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Mehra, Mandeep" sort="Mehra, Mandeep" uniqKey="Mehra M" first="Mandeep" last="Mehra">Mandeep Mehra</name><affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Alton Ochsner Medical Foundation</s1><s2>New Orleans, Louisiana</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Louisiane</region></placeName></affiliation></author><author><name sortKey="Constanzo, Maria Rosa" sort="Constanzo, Maria Rosa" uniqKey="Constanzo M" first="Maria Rosa" last="Constanzo">Maria Rosa Constanzo</name><affiliation wicri:level="2"><inist:fA14 i1="13"><s1>Rush-Preshyterian-St Luke's Medical Center</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Hummel, Manfred" sort="Hummel, Manfred" uniqKey="Hummel M" first="Manfred" last="Hummel">Manfred Hummel</name><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Deutsches Herzzentrum</s1><s2>Berlin</s2><s3>DEU</s3><sZ>16 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Johnson, Jay" sort="Johnson, Jay" uniqKey="Johnson J" first="Jay" last="Johnson">Jay Johnson</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>University of California at Los Angeles</s1><s2>Los Angeles, California</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region 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cardiac transplant recipients</title><author><name sortKey="Eisen, Howard J" sort="Eisen, Howard J" uniqKey="Eisen H" first="Howard J." last="Eisen">Howard J. Eisen</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Drexel University College of Medicine</s1><s2>Philadelphia, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Kobashigawa, Jon" sort="Kobashigawa, Jon" uniqKey="Kobashigawa J" first="Jon" last="Kobashigawa">Jon Kobashigawa</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>University of California at Los Angeles</s1><s2>Los Angeles, California</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Keogh, Anne" sort="Keogh, Anne" uniqKey="Keogh A" first="Anne" last="Keogh">Anne Keogh</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>St Vincent's Hospital</s1><s2>Sydney, New South Wales</s2><s3>AUS</s3><sZ>3 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>St Vincent's Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Bourge, Robert" sort="Bourge, Robert" uniqKey="Bourge R" first="Robert" last="Bourge">Robert Bourge</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>University of Alabama Birmingham</s1><s2>Birmingham, Alabama</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Alabama</region></placeName></affiliation></author><author><name sortKey="Renlund, Dale" sort="Renlund, Dale" uniqKey="Renlund D" first="Dale" last="Renlund">Dale Renlund</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>University of Utah</s1><s2>Salt Lake City, Utah</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Mentzer, Robert" sort="Mentzer, Robert" uniqKey="Mentzer R" first="Robert" last="Mentzer">Robert Mentzer</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>University of Wisconsin</s1><s2>Madison, Wisconsin</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Alderman, Edwin" sort="Alderman, Edwin" uniqKey="Alderman E" first="Edwin" last="Alderman">Edwin Alderman</name><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Stanford University</s1><s2>Palo Alto, California</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Valantine, Hannah" sort="Valantine, Hannah" uniqKey="Valantine H" first="Hannah" last="Valantine">Hannah Valantine</name><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Stanford University</s1><s2>Palo Alto, California</s2><s3>USA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Dureau, Georges" sort="Dureau, Georges" uniqKey="Dureau G" first="Georges" last="Dureau">Georges Dureau</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Hospices Civils de Lyon Hopital</s1><s2>Lyon</s2><s3>FRA</s3><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Mancini, Donna" sort="Mancini, Donna" uniqKey="Mancini D" first="Donna" last="Mancini">Donna Mancini</name><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Columbia University College of Physicians and Surgeons</s1><s2>New York, New York</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Mamelok, Richard" sort="Mamelok, Richard" uniqKey="Mamelok R" first="Richard" last="Mamelok">Richard Mamelok</name><affiliation wicri:level="2"><inist:fA14 i1="10"><s1>mamelok Consulting</s1><s2>Palo Alto, California</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Gordon, Robert" sort="Gordon, Robert" uniqKey="Gordon R" first="Robert" last="Gordon">Robert Gordon</name><affiliation wicri:level="2"><inist:fA14 i1="11"><s1>Hoffmann-La Roche</s1><s2>Nutley, New Jersey</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Wang, Whedy" sort="Wang, Whedy" uniqKey="Wang W" first="Whedy" last="Wang">Whedy Wang</name><affiliation wicri:level="2"><inist:fA14 i1="11"><s1>Hoffmann-La Roche</s1><s2>Nutley, New Jersey</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Mehra, Mandeep" sort="Mehra, Mandeep" uniqKey="Mehra M" first="Mandeep" last="Mehra">Mandeep Mehra</name><affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Alton Ochsner Medical Foundation</s1><s2>New Orleans, Louisiana</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Louisiane</region></placeName></affiliation></author><author><name sortKey="Constanzo, Maria Rosa" sort="Constanzo, Maria Rosa" uniqKey="Constanzo M" first="Maria Rosa" last="Constanzo">Maria Rosa Constanzo</name><affiliation wicri:level="2"><inist:fA14 i1="13"><s1>Rush-Preshyterian-St Luke's Medical Center</s1><s2>Chicago, Illinois</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Hummel, Manfred" sort="Hummel, Manfred" uniqKey="Hummel M" first="Manfred" last="Hummel">Manfred Hummel</name><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Deutsches Herzzentrum</s1><s2>Berlin</s2><s3>DEU</s3><sZ>16 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Johnson, Jay" sort="Johnson, Jay" uniqKey="Johnson J" first="Jay" last="Johnson">Jay Johnson</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>University of California at Los Angeles</s1><s2>Los Angeles, California</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j" type="main">The Journal of heart and lung transplantation</title><title level="j" type="abbreviated">J. heart lung transplant.</title><idno type="ISSN">1053-2498</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The Journal of heart and lung transplantation</title><title level="j" type="abbreviated">J. heart lung transplant.</title><idno type="ISSN">1053-2498</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibiotic</term><term>Antiviral</term><term>Azathioprine</term><term>Cardiovascular disease</term><term>Comparative study</term><term>Double blind study</term><term>Heart</term><term>Homotransplantation</term><term>Immunosuppressive agent</term><term>Long term</term><term>Mofetil</term><term>Mycophenolate mofetil</term><term>Mycophenolic acid</term><term>Prognosis</term><term>Randomization</term><term>Respiratory disease</term><term>Surgery</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Appareil circulatoire pathologie</term><term>Appareil respiratoire pathologie</term><term>Mycophenolate mofetil</term><term>Acide mycophénolique</term><term>Mofétil</term><term>Long terme</term><term>Pronostic</term><term>Randomisation</term><term>Etude double insu</term><term>Immunodépresseur</term><term>Etude comparative</term><term>Azathioprine</term><term>Coeur</term><term>Homotransplantation</term><term>Chirurgie</term><term>Antiviral</term><term>Antibiotique</term><term>Traitement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Chirurgie</term><term>Antibiotique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: This study reports the 36-month results of a randomized, double-blind, active-controlled trial of mycophenolate mofetil (MMF) vs azathioprine (AZA) in heart transplant patients. Methods: Patients were randomized at the time of transplant to receive MMF (1,500 mg twice a day, N = 327) or AZA (1.5 to 3 mg/kg in 4 daily doses, N = 323) in addition to cyclosporine and corticosteroids; 289 patients in each group received study drug. Data were analyzed in all randomized patients (enrolled) and in patients who received study medications (treated). Clinical and graft assessments continued for 36 months. Results: For the co-primary end-point, 53 of 289 (18.3%) AZA-treated patients either died or received another transplant compared with 34 of 289 (11.8%) MMF-treated patients (p < 0.01). Time to retransplantation or patient death was significantly shorter for AZA- than MMF-treated patients (p = 0.029). In patients undergoing intravascular ultrasound, the change in mean maximal intimal thickness was less for the MMF group than for the AZA group (0.06 ± 0.03 mm vs 0.13 ± 0.03 mm, respectively; p = 0.056). No significant differences between treatments were observed in quantitative coronary angiographic measurements of transplant coronary vasculopathy. Congestive heart failure, atrial arrhythmia and leukopenia were more common in the AZA group, whereas diarrhea, esophagitis, Herpes simplex, Herpes zoster and cytomegalovirus (CMV) tissue invasion were more common in MMF-treated patients. Conclusion: MMF reduces mortality and graft loss up to 36 months after transplantation.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>États-Unis</li></country><region><li>Alabama</li><li>Auvergne-Rhône-Alpes</li><li>Berlin</li><li>Californie</li><li>Illinois</li><li>Louisiane</li><li>New Jersey</li><li>Pennsylvanie</li><li>Rhône-Alpes</li><li>Utah</li><li>Wisconsin</li><li>État de New York</li></region><settlement><li>Berlin</li><li>Lyon</li></settlement></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Eisen, Howard J" sort="Eisen, Howard J" uniqKey="Eisen H" first="Howard J." last="Eisen">Howard J. Eisen</name></region><name sortKey="Alderman, Edwin" sort="Alderman, Edwin" uniqKey="Alderman E" first="Edwin" last="Alderman">Edwin Alderman</name><name sortKey="Bourge, Robert" sort="Bourge, Robert" uniqKey="Bourge R" first="Robert" last="Bourge">Robert Bourge</name><name sortKey="Constanzo, Maria Rosa" sort="Constanzo, Maria Rosa" uniqKey="Constanzo M" first="Maria Rosa" last="Constanzo">Maria Rosa Constanzo</name><name sortKey="Gordon, Robert" sort="Gordon, Robert" uniqKey="Gordon R" first="Robert" last="Gordon">Robert Gordon</name><name sortKey="Johnson, Jay" sort="Johnson, Jay" uniqKey="Johnson J" first="Jay" last="Johnson">Jay Johnson</name><name sortKey="Kobashigawa, Jon" sort="Kobashigawa, Jon" uniqKey="Kobashigawa J" first="Jon" last="Kobashigawa">Jon Kobashigawa</name><name sortKey="Mamelok, Richard" sort="Mamelok, Richard" uniqKey="Mamelok R" first="Richard" last="Mamelok">Richard Mamelok</name><name sortKey="Mancini, Donna" sort="Mancini, Donna" uniqKey="Mancini D" first="Donna" last="Mancini">Donna Mancini</name><name sortKey="Mehra, Mandeep" sort="Mehra, Mandeep" uniqKey="Mehra M" first="Mandeep" last="Mehra">Mandeep Mehra</name><name sortKey="Mentzer, Robert" sort="Mentzer, Robert" uniqKey="Mentzer R" first="Robert" last="Mentzer">Robert Mentzer</name><name sortKey="Renlund, Dale" sort="Renlund, Dale" uniqKey="Renlund D" first="Dale" last="Renlund">Dale Renlund</name><name sortKey="Valantine, Hannah" sort="Valantine, Hannah" uniqKey="Valantine H" first="Hannah" last="Valantine">Hannah Valantine</name><name sortKey="Wang, Whedy" sort="Wang, Whedy" uniqKey="Wang W" first="Whedy" last="Wang">Whedy Wang</name></country><country name="Australie"><noRegion><name sortKey="Keogh, Anne" sort="Keogh, Anne" uniqKey="Keogh A" first="Anne" last="Keogh">Anne Keogh</name></noRegion></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Dureau, Georges" sort="Dureau, Georges" uniqKey="Dureau G" first="Georges" last="Dureau">Georges Dureau</name></region></country><country name="Allemagne"><region name="Berlin"><name sortKey="Hummel, Manfred" sort="Hummel, Manfred" uniqKey="Hummel M" first="Manfred" last="Hummel">Manfred Hummel</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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